Alteration of the gut microbiota together with an increase in intestinal permeability and persistent inflammatory responses are thought to be critical factors in the pathogenesis of inflammatory bowel disease (IBD). Taking benefit of these knowledges, a proper strategy to address the selection of efficient probiotics is needed more than ever. The present study investigated a collection of 11 strains of lactobacilli and bifidobacteria by combining in vitro approaches to select strains with anti-inflammatory activity and capacity to enhance intestinal barrier function. We identified five strains, with different characteristics that entail a high potential for the management of IBD, notably two strains that were highly protective in two different models of colitis. Notably, our results support the hypothesis that the capacity of the strains to alleviate inflammation is in part mediated by the improvement of the intestinal barrier and the restoration of tight junction proteins.

肠道菌群的改变以及肠道通透性的增加和持续的炎症反应被认为是炎症性肠病（IBD）发病机理中的关键因素。利用这些知识，比以往任何时候都更需要一种解决有效益生菌选择的正确策略。本研究通过体外联合研究收集了11株乳酸菌和双歧杆菌菌株种方法来选择具有抗炎活性和增强肠屏障功能能力的菌株。我们确定了五种具有不同特征的菌株，这些菌株具有很高的IBD管理潜力，尤其是两种在两种不同的结肠炎模型中具有高度保护性的菌株。值得注意的是，我们的结果支持以下假设：菌株缓解炎症的能力部分由肠屏障的改善和紧密连接蛋白的恢复介导。