Phthalates are endocrine-disrupting for their ability to change the normal function of human endocrine system. Their action on the reproductive system, both on male and female, is the most one investigated by international scientific community. The aim of this systematic review was to gather the available information regarding the role of phthalates on breast carcinogenesis focusing our research in their intake through the diet. Research was performed according the PRISMA methodology and 25 scientific articles published between 2000 and 2018 were selected. The main source of exposure to phthalates is diet, mainly through the consumption of food and beverages wrapped in different plastic packaging. Several in vitro studies suggest that certain phthalates may be associated to breast cancer since they can bind and activate the estrogen receptors. However, results of epidemiological studies are debated, yet. It's necessary to plan the future studies more carefully to have more representative data on phthalate exposure by replacing urinary matrix with piliferous one, by including as confounding factors not only the other risk factors but also prevention one as diet and miRNA expression and, finally, by direct the study considering not only the estrogenic activity of phthalates and so including also the ER negative tumors.

邻苯二甲酸盐因其改变人类内分泌系统正常功能的能力而破坏内分泌。它们对男性和女性生殖系统的作用是国际科学界调查的最多的一种。本系统综述的目的是收集有关邻苯二甲酸盐在乳癌发生中的作用的可用信息，从而将我们的研究重点放在饮食中。根据PRISMA方法进行了研究，并选择了2000年至2018年发表的25篇科学文章。接触邻苯二甲酸盐的主要来源是饮食，主要是通过食用包装在不同塑料包装中的食品和饮料。几种体外研究表明某些邻苯二甲酸酯可能与乳腺癌有关，因为它们可以结合并激活雌激素受体。但是，流行病学研究的结果尚有争议。有必要通过仔细地计划未来的研究，以通过用毛毛虫代替尿基质来获得更多邻苯二甲酸盐暴露的代表性数据，不仅将其他危险因素作为混杂因素，而且还将饮食和miRNA表达作为预防因素，最后通过指导研究时不仅要考虑邻苯二甲酸酯的雌激素活性，而且还应考虑到ER阴性肿瘤。