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One-Pot Construction of 3-Phthalimido-1,5-benzodiazepine-2-one Derivatives via in situ Activation of N,N-Phthaloyl-serine
Synlett ( IF 1.7 ) Pub Date : 2018-06-07 , DOI: 10.1055/s-0037-1610026 Nobuhiro Obara 1 , Takeshi Watanabe 2 , Tomohiro Asakawa 2, 3 , Toshiyuki Kan 2 , Takao Tanaka 1
Synlett ( IF 1.7 ) Pub Date : 2018-06-07 , DOI: 10.1055/s-0037-1610026 Nobuhiro Obara 1 , Takeshi Watanabe 2 , Tomohiro Asakawa 2, 3 , Toshiyuki Kan 2 , Takao Tanaka 1
Affiliation
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The Michael addition of dehydroalanine-activated ester in situ generated from N,N-phthaloyl-serine with o-phenylenediamine followed by cyclization has been established under mild conditions, which afforded 3-phthalimido-1,5-benzodiazepine-2-one derivatives in moderate to good yields.
中文翻译：
通过原位激活 N,N-Phthaloyl-serine 一锅法构建 3-Phthalimido-1,5-benzodiazepine-2-one 衍生物
N,N-邻苯二甲酰丝氨酸与邻苯二胺环化反应生成脱氢丙氨酸活化酯的迈克尔加成反应，在温和条件下得到3-邻苯二甲酰亚胺-1,5-苯并二氮杂-2-酮衍生物。中等至良好的产量。
更新日期：2018-06-07
中文翻译：
通过原位激活 N,N-Phthaloyl-serine 一锅法构建 3-Phthalimido-1,5-benzodiazepine-2-one 衍生物
N,N-邻苯二甲酰丝氨酸与邻苯二胺环化反应生成脱氢丙氨酸活化酯的迈克尔加成反应，在温和条件下得到3-邻苯二甲酰亚胺-1,5-苯并二氮杂-2-酮衍生物。中等至良好的产量。
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