Stimuli-responsive delivery systems for cancer therapy have been increasingly used to promote the on-demand therapeutic efficacy of anticancer drugs and, in some cases, simultaneously generate heat in response to a stimulus, resulting in hyperthermia. However, their application is still limited due to the systemic drawbacks of intravenous delivery, such as rapid clearance from the bloodstream and the repeat injections required for sustained safe dosage, which can cause overdosing. Here, we propose a gold (Au)-coated nanoturf structure as an implantable therapeutic interface for near-infrared (NIR)-mediated on-demand hyperthermia chemotherapy. The Au nanoturf possessed long-lasting doxorubicin (DOX) duration, which helps facilitate drug release in a sustained and prolonged manner. Moreover, the Au-coated nanoturf provides reproducible hyperthermia induced by localized surface plasmon resonances under NIR irradiation. Simultaneously, the NIR-mediated temperature increase can promote on-demand drug release at desired time points. For in vivo analysis, the Au nanoturf structure was applied on an esophageal stent, which needs sustained anticancer treatment to prevent tumor recurrence on the implanted surface. This thermo- and chemo-esophageal stent induced significant cancer cell death with released drug and hyperthermia. These phenomena were also confirmed by theoretical analysis. The proposed strategy provides a solution to achieve enhanced thermo-/chemotherapy and has broad applications in sustained cancer treatments.

中文翻译：

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从金纳米草皮按需释放热和化学治疗食管支架

用于癌症治疗的刺激响应性递送系统已被越来越多地用于促进抗癌药物的按需治疗功效，并且在某些情况下，由于刺激而同时产生热量，从而导致体温过高。然而，由于静脉内递送的系统性缺陷，例如从血流中快速清除和持续安全剂量所需的重复注射，其应用仍然受到限制，这可能会导致用药过量。在这里，我们提出了金（Au）涂层的纳米草皮结构，作为近红外（NIR）介导的按需高温疗法的可植入治疗界面。金纳米草皮具有长效的阿霉素（DOX）持续时间，有助于以持续和延长的方式促进药物释放。而且，Au包覆的纳米草皮提供了可再生的热疗，该热疗是由NIR照射下的局部表面等离振子共振诱导的。同时，NIR介导的温度升高可以促进所需时间点上的按需药物释放。为了在体内分析中，Au纳米草皮结构应用于食道支架，该支架需要持续的抗癌治疗，以防止肿瘤在植入表面复发。这种热食道和化学食道支架通过释放的药物和热疗引起明显的癌细胞死亡。理论分析也证实了这些现象。所提出的策略提供了实现增强的热化学疗法的解决方案，并在持续的癌症治疗中具有广泛的应用。