Improving the supply of O₂ and the circulation lifetime of photosensitizers for photodynamic therapy (PDT) in vivo would be a promising approach to eliminate hypoxic tumors. Herein, by taking advantage of the significant gas-adsorption capability of metal-organic frameworks (MOFs), a biomimetic O₂-evolving photodynamic therapy (PDT) nanoplatform with long circulating properties was fabricated. Zirconium (IV)-based MOF (UiO-66) was used as a vehicle for O₂ storing, then conjugated with indocyanine green (ICG) by coordination reaction, and further coated with red blood cell (RBC) membranes. Upon 808 nm laser irradiation, the initial singlet oxygen (¹O₂) generated by ICG would decompose RBC membranes. At the same time, The photothermal property of ICG could facilitate the burst release of O₂ from UiO-66. Subsequently, the generated O₂ could significantly improve the PDT effects on hypoxic tumor. Owing to the advantages of long circulation and O₂ self-sufficient, the designed nanotherapeutic agent can improve the efficiency of treatment against hypoxia tumor via PDT. Hence, this study presents a new paradigm for co-delivery of O₂ and photosensitizers, and provides a new avenue to eliminate hypoxic tumors.

改善体内光动力疗法（PDT）的O ₂的供应和光敏剂的循环寿命将是消除缺氧肿瘤的一种有前途的方法。在此，通过利用金属-有机骨架（MOF）的强大的气体吸附能力，制造了具有长循环特性的仿生O ₂演化光动力学疗法（PDT）纳米平台。将基于锆（IV）的MOF（UiO-66）用作O ₂储存的载体，然后通过配位反应将其与吲哚菁绿（ICG）偶联，然后进一步涂以红血球（RBC）膜。在808 nm激光照射下，初始单重态氧（¹ O ₂ICG生成的）会分解RBC膜。同时，ICG的光热性质可以促进O ₂从UiO-66的突发释放。随后，生成的O ₂可以显着改善PDT对缺氧肿瘤的作用。由于长循环和O的优点₂自给自足，所设计的纳米治疗剂可以提高治疗的对缺氧肿瘤效率通过PDT。因此，本研究提出了O ₂和光敏剂共同递送的新范例，并为消除缺氧肿瘤提供了新途径。