Xerogel modified diatomaceous earth microparticles for controlled drug release studies†,New Journal of Chemistry

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Xerogel modified diatomaceous earth microparticles for controlled drug release studies†
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2018-06-07 00:00:00 , DOI: 10.1039/c8nj01238e
U. T. Uthappa _{1,

2,

3,

4} , G. Sriram _{1,

2,

3,

4} , Varsha Brahmkhatri _{1,

2,

3,

4} , Madhuprasad Kigga _{1,

2,

3,

4} , Ho-Young Jung _{5,

6,

7,

8} , Tariq Altalhi _{9,

10,

11,

12,

13} , Gururaj M. Neelgund _{9,

14,

15,

16} , Mahaveer D. Kurkuri _{1,

2,

3,

4}

Affiliation

Naturally available diatomaceous earth (DE) microparticles are ideal candidates for drug delivery due to their excellent features like biocompatibility, non-toxicity, porosity, high surface area and ease of surface modification. On the other hand, they have some limitations, especially in drug delivery applications, such as poor drug loading capacity and a very high initial burst release. In order to address these drawbacks, we have surface modified the diatoms with silica xerogel, which forms a novel hybrid material. The modification process was carried out by a facile sol–gel method, the silica xerogel decorated DE microparticles were extensively characterized by SEM, BET, ATR-IR spectroscopy and XRD in order to confirm the covalent linkage of the new material on the surface of the DE microparticles. The prepared hybrid material DE-XER (xerogel) acts as a pH-sensitive micro drug carrier for diclofenac sodium (DS) drug. The results indicate that surface modification plays a critical role, enhancing the drug loading capacity in comparison with neat DE microparticles, achieving effective controlled release. Furthermore, the obtained drug release data were fitted to the zero order model to understand the drug release mechanism.

中文翻译：

Xerogel改性的硅藻土微粒用于受控药物释放研究†

天然存在的硅藻土（DE）微粒具有生物相容性，无毒，多孔，高表面积和易于表面修饰等优异特性，因此是药物输送的理想选择。另一方面，它们具有一些局限性，特别是在药物输送应用中，例如不良的药物装载能力和很高的初始爆发释放。为了解决这些缺点，我们用二氧化硅干凝胶对硅藻进行了表面改性，从而形成了一种新型的杂化材料。改性过程通过简便的溶胶-凝胶法进行，二氧化硅干凝胶修饰的DE微粒通过SEM，BET，ATR-IR光谱和XRD进行了广泛表征，以确认新材料在表面上的共价键。 DE微粒。制备的杂化材料DE-XER（干凝胶）充当双氯芬酸钠（DS）药物的pH敏感微药物载体。结果表明，表面修饰起着关键作用，与纯净的DE微粒相比，增强了载药量，实现了有效的控释。此外，将获得的药物释放数据拟合到零级模型以了解药物释放机理。

更新日期：2018-06-07

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