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Synthesis of Azido‐Glycans for Chemical Glycomodification of Proteins
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-09 , DOI: 10.1002/ejoc.201800602 Mirella Wawryszyn 1, 2 , Paul F. Sauter 1 , Martin Nieger 3 , Martin R. M. Koos 4 , Christine Koehler 5, 6, 7 , Burkhard Luy 1, 4 , Edward A. Lemke 5, 6, 7 , Stefan Bräse 1, 2, 8
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-09 , DOI: 10.1002/ejoc.201800602 Mirella Wawryszyn 1, 2 , Paul F. Sauter 1 , Martin Nieger 3 , Martin R. M. Koos 4 , Christine Koehler 5, 6, 7 , Burkhard Luy 1, 4 , Edward A. Lemke 5, 6, 7 , Stefan Bräse 1, 2, 8
Affiliation
An azido‐glycan core structure was modified into the protected N‐glycan pentasaccharide core structure. The azido function allows for chemical ligation with recombinantly modified proteins featuring noncanonical cyclooctyne amino acids, providing access to customized glycopatterns of glycoproteins.
中文翻译:
叠氮基聚糖的合成,用于蛋白质的化学糖化。
叠氮基聚糖核心结构被修改为受保护的N聚糖五糖核心结构。叠氮基功能允许与具有非典型环辛炔氨基酸的重组修饰蛋白进行化学连接,从而获得糖蛋白的定制糖模式。
更新日期:2018-08-09
中文翻译:
叠氮基聚糖的合成,用于蛋白质的化学糖化。
叠氮基聚糖核心结构被修改为受保护的N聚糖五糖核心结构。叠氮基功能允许与具有非典型环辛炔氨基酸的重组修饰蛋白进行化学连接,从而获得糖蛋白的定制糖模式。