Synthesis of Azido‐Glycans for Chemical Glycomodification of Proteins,European Journal of Organic Chemistry

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Synthesis of Azido‐Glycans for Chemical Glycomodification of Proteins
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-09 , DOI: 10.1002/ejoc.201800602
Mirella Wawryszyn _{1,

2} , Paul F. Sauter ₁ , Martin Nieger ₃ , Martin R. M. Koos ₄ , Christine Koehler _{5,

6,

7} , Burkhard Luy _{1,

4} , Edward A. Lemke _{5,

6,

7} , Stefan Bräse _{1,

2,

8}

Affiliation

An azido‐glycan core structure was modified into the protected N‐glycan pentasaccharide core structure. The azido function allows for chemical ligation with recombinantly modified proteins featuring noncanonical cyclooctyne amino acids, providing access to customized glycopatterns of glycoproteins.