We reported the facile preparation of self-fluorescent mesoporous silica nanoparticles based on a triple-role curcumin polymer shell as stimuli-responsive multifunctional nanocarriers for drug delivery. This curcumin polymer shell integrates multiple function of acting as fluorescent agents, increasing the drug loading ratio of curcumin, and controlling the open and close of the pores in a “smart” way. This novel drug nanocarrier will inspire the development of smart and self-fluorescent drug nanocarrier to achieve imaging and therapeutic goals for cancer therapy.

中文翻译：

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姜黄素聚合物包衣，自发荧光和对刺激有反应的多功能介孔二氧化硅纳米颗粒，用于药物输送

我们报道了基于三角色姜黄素聚合物壳作为刺激响应的多功能纳米载体用于药物传递的自发荧光的介孔二氧化硅纳米粒子的简便制备。该姜黄素聚合物外壳具有多种功能，可充当荧光剂，增加姜黄素的载药率并以“智能”方式控制孔的打开和关闭。这种新颖的药物纳米载体将激发智能和自发荧光的药物纳米载体的开发，以实现癌症治疗的成像和治疗目标。