Effects of Fiber Purified Extract of Carob Fruit on Fat Digestion and Postprandial Lipemia in Healthy Rats,Journal of Agricultural and Food Chemistry

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Effects of Fiber Purified Extract of Carob Fruit on Fat Digestion and Postprandial Lipemia in Healthy Rats
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-06-07 00:00:00 , DOI: 10.1021/acs.jafc.8b01476
A. Macho-González _{1,

2,

3} , A. Garcimartín _{2,

3,

4} , F. Naes _{1,

2,

3} , M. E. López-Oliva _{2,

3,

5} , A. Amores-Arrojo ₁ , M. J. González-Muñoz _{2,

3,

6} , S. Bastida _{1,

2,

3} , J. Benedí _{2,

3,

4} , F. J. Sánchez-Muniz _{1,

2,

3}

Affiliation

Increased postprandial lipemia is a cardiovascular disease (CVD) risk factor. Carob fruit extract (CFE) contains condensed tannins, and their intake has been inversely related to CVD. The objective was to evaluate the in vitro pancreatic lipase activity in the presence of CFE and the in vivo effect of CFE on postprandial lipemia of healthy Wistar rats in acute and subchronic digestibility studies and to relate it with changes in fat digestion and absorption. CFE significantly reduced pancreatic lipase activity. A peak delay and a dose-dependent decrease in plasma triglyceride and cholesterol areas under the curve were observed, effects that increased after the subchronic treatment. The levels of nondigested, nonabsorbed triglycerides of the remaining intestinal lumen fat were significantly higher in the maximum dose of CFE administrated versus the control (P < 0.05). This study demonstrates for the first time the hypolipemic properties of CFE from the first administration, modifying postprandial lipemia by reducing the extents of fat digestion and absorption.

中文翻译：

纤维纯化的角豆果提取物对健康大鼠脂肪消化和餐后血脂的影响

餐后血脂增加是心血管疾病（CVD）的危险因素。角豆果实提取物（CFE）包含浓缩的单宁，其摄入量与CVD呈负相关。目的是在急性和亚慢性消化率研究中，评估存在CFE时的体外胰腺脂肪酶活性以及CFE对健康Wistar大鼠餐后血脂的体内作用，并将其与脂肪消化吸收的变化联系起来。CFE显着降低了胰腺脂肪酶的活性。观察到曲线下血浆甘油三酸酯和胆固醇面积的峰值延迟和剂量依赖性降低，在亚慢性治疗后效果增加。未消化的水平P <0.05）。这项研究首次证明了首次给药后CFE的降血脂特性，可通过减少脂肪消化和吸收的程度来改善餐后血脂。

更新日期：2018-06-07

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