Locally Deployable Nanofiber Patch for Sequential Drug Delivery in Treatment of Primary and Advanced Orthotopic Hepatomas,ACS Nano

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Locally Deployable Nanofiber Patch for Sequential Drug Delivery in Treatment of Primary and Advanced Orthotopic Hepatomas
ACS Nano ( IF 15.8 ) Pub Date : 2018-06-06 00:00:00 , DOI: 10.1021/acsnano.8b01729
Jiannan Li _{1,

2} , Weiguo Xu ₁ , Di Li ₁ , Tongjun Liu ₂ , Yu Shrike Zhang ₃ , Jianxun Ding ₁ , Xuesi Chen ₁

Affiliation

With unsatisfactory effects of systemic chemotherapy for treatment of unresectable or advanced hepatoma, local and sustained delivery of chemotherapeutic agents is becoming a promising solution. The in situ administered platforms increase the drug concentrations in tumor regions, decrease the side effects to organs, prevent the damage to vascular endothelium, and reduce the frequency of drug administration. The prevalent strategy based on minimally invasive transarterial chemoembolization oftentimes induces upper gastrointestinal hemorrhage, liver failure, and liver abscess. In addition, integrating various antitumor drugs in one platform, especially the drugs with different hydrophilic/hydrophobic properties, and achieving sustained and/or sequential release profiles to synergistically inhibit cancer progression remain challenging. In this study, a local drug delivery system made of an emulsion-electrospun polymer patch was developed, which contained hydrophobic 10-hydroxycamptothecin (HCPT) and hydrophilic tea polyphenols (TP) in the shell and core of the nanofiber, respectively. Due to this core–sheath structure, HCPT and TP exhibited sustained and sequential releases first with HCPT followed by TP. HCPT was used to suppress the proliferation and malignant transformation of hepatoma, whereas TP was aimed to decrease the levels of oxygen free radicals and further prevent the invasion and metastasis of tumor cells. Our study presented the potential superiority of this class of core–sheath structured nanofiber membranes in localized treatment of both primary and advanced orthotopic hepatomas.

中文翻译：

局部可部署的纳米纤维补丁，用于序贯给药的原发性和晚期原位肝癌的治疗

由于全身化学疗法对于不能切除或进展期的肝癌的治疗效果不理想，局部和持续递送化学治疗剂正成为一种有前途的解决方案。在原位给药平台可增加肿瘤区域的药物浓度，减少对器官的副作用，防止对血管内皮的损害，并减少给药频率。基于微创经动脉化学栓塞的流行策略通常会诱发上消化道出血，肝功能衰竭和肝脓肿。另外，将各种抗肿瘤药物，尤其是具有不同亲水/疏水性质的药物整合到一个平台中，以及获得持续和/或顺序释放的特征以协同抑制癌症进展仍然是具有挑战性的。在这项研究中，开发了由乳液静电纺丝聚合物贴片制成的局部药物递送系统，在纳米纤维的壳和芯中分别含有疏水性10-羟基喜树碱（HCPT）和亲水性茶多酚（TP）。由于这种核心-鞘结构，HCPT和TP首先显示出持续释放和顺序释放，然后依次是HCPT和TP。HCPT用于抑制肝癌的增殖和恶性转化，而TP旨在降低氧自由基的水平并进一步防止肿瘤细胞的侵袭和转移。我们的研究表明，这种类型的芯-鞘结构纳米纤维膜在原发性和晚期原位肝癌的局部治疗中具有潜在的优势。HCPT用于抑制肝癌的增殖和恶性转化，而TP旨在降低氧自由基的水平并进一步防止肿瘤细胞的侵袭和转移。我们的研究表明，这种类型的芯-鞘结构纳米纤维膜在原发性和晚期原位肝癌的局部治疗中具有潜在的优势。HCPT用于抑制肝癌的增殖和恶性转化，而TP旨在降低氧自由基的水平并进一步防止肿瘤细胞的侵袭和转移。我们的研究表明，这种类型的芯-鞘结构纳米纤维膜在原发性和晚期原位肝癌的局部治疗中具有潜在的优势。

更新日期：2018-06-06

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