This study explores the influence of different synthesis methods and drying conditions in the preparation of sodium alginate-derivate xerogels presenting interesting disintegrant functionalities. Xerogels containing alginic acid (AA) or calcium alginate (CaA) and a mixture of both, AA/CaA, were isolated using two different drying methods oven and rotary evaporation. AA showed the best wettability behavior, in contrast to the rigid crosslinked CaA structure which showed a limited rate of water penetration. Interestingly, xerogel containing AA dried in the oven showed an enhanced maximum water uptake. Oven drying seems to favor the isolation of materials presenting good tabletability. Compression parameters of the formulations (tensile strength, elastic energy and porosity) were not affected by their presence (5%) in the design of OroDispersible Mini Tablets. In vitro disintegration results highlighted the water wicking as the key factor leading the disintegration mechanism of these materials. These results show promise of potential properties for the development of super disintegrant excipients.

这项研究探索了不同的合成方法和干燥条件对藻酸钠衍生干凝胶制备的影响，这些凝胶具有令人关注的崩解功能。使用烤箱和旋转蒸发两种不同的干燥方法分离出含有海藻酸（AA）或海藻酸钙（CaA）和二者的混合物AA / CaA的干凝胶。与显示出有限的水渗透率的刚性交联的CaA结构相反，AA显示出最佳的润湿性。有趣的是，在烘箱中干燥的含有AA的干凝胶显示出最大的吸水率。烤箱干燥似乎有利于分离具有良好压片性的材料。配方的压缩参数（拉伸强度，在OroDispersible Mini Tablets的设计中，弹性能量和孔隙率不受其存在（5％）的影响。一世体外崩解结果突出了吸水作用是导致这些材料崩解机理的关键因素。这些结果显示出开发超崩解性赋形剂的潜在性能的希望。