Background

Bioactive natural compounds have received considerable attention due to their health benefits, including anti-oxidant, anti-cancer, anti-diabetes and cardiovascular disease-preventing functions. However, the stability of these sensitive compounds can be influenced by unfavourable environmental conditions during processing and storage. In addition, delivery of bioactive compounds via the oral route is restricted by various physiological barriers, including a harsh pH, gastrointestinal enzymes, the mucus layer, and the epithelium. Intelligent delivery systems are a promising method to protect bioactive molecules from degradation and improve their bioavailability.

Scope and approach

We have demonstrated the physicochemical and physiological GI conditions. The structural composition of the epithelium and transport mechanisms of bioactives and nanoparticles across the intestinal epithelium were discussed. The effects of enhanced aqueous solubility, stability, bioaccessibility and bioavailability after encapsulation were illustrated. Furthermore, novel intelligent carriers that are responsive to the oral route, pH, enzymes and cell receptors were also discussed.

Key findings and conclusions

This comprehensive multidisciplinary review provides useful guidelines for the application of bioactive compounds in the food industry. Intelligent carrier systems are designed to improve the low solubility, poor stability and low permeability of the gastrointestinal tract, and they have the potential to improve oral bioavailability.

中文翻译：

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食品中生物活性化合物的智能递送系统：物理化学和生理条件，吸收机制，障碍和响应策略

背景

生物活性天然化合物因其有益健康的作用而受到了广泛的关注，包括抗氧化剂，抗癌药，抗糖尿病药和预防心血管疾病的功能。但是，这些敏感化合物的稳定性会受到加工和存储过程中不利环境条件的影响。另外，通过口服途径递送生物活性化合物受到各种生理障碍的限制，包括苛刻的pH，胃肠道酶，粘液层和上皮。智能递送系统是保护生物活性分子免于降解并提高其生物利用度的一种有前途的方法。

范围和方法

我们已经证明了理化和生理的胃肠道疾病。讨论了上皮的结构组成以及生物活性物质和纳米颗粒跨肠上皮的转运机制。说明了包封后提高的水溶性，稳定性，生物可及性和生物利用度的作用。此外，还讨论了对口服途径，pH，酶和细胞受体有反应的新型智能载体。

主要发现和结论

这项全面的多学科综述为生物活性化合物在食品工业中的应用提供了有用的指导。智能载体系统旨在改善胃肠道的低溶解度，稳定性差和低渗透性，并且具有改善口服生物利用度的潜力。