Polymers, ceramics and metals have historically dominated the application of materials in medicine. Yet rationally designed materials that exploit specific, directional, tunable and reversible non-covalent interactions offer unprecedented advantages: they enable modular and generalizable platforms with tunable mechanical, chemical and biological properties. Indeed, the reversible nature of supramolecular interactions gives rise to biomaterials that can sense and respond to physiological cues, or that mimic the structural and functional aspects of biological signalling. In this Review, we discuss the properties of several supramolecular biomaterials, as well as their applications in drug delivery, tissue engineering, regenerative medicine and immunology. We envision that supramolecular biomaterials will contribute to the development of new therapies that combine highly functional materials with unmatched patient- and application-specific tailoring of both material and biological properties.

历史上，聚合物，陶瓷和金属主导着材料在医学中的应用。然而，利用特定的，方向性的，可调的和可逆的非共价相互作用进行合理设计的材料具有前所未有的优势：它们使具有模块化的，可通用的平台具有可调的机械，化学和生物学特性。实际上，超分子相互作用的可逆性质产生了可以感知并响应生理线索或模仿生物信号传导的结构和功能方面的生物材料。在这篇综述中，我们讨论了几种超分子生物材料的特性，以及它们在药物递送，组织工程，再生医学和免疫学中的应用。