Among the most promising strategies currently assayed against IgE-mediated allergic diseases stands the possibility of using immunomodulating peptides to induce oral tolerance toward offending food allergens or even to prevent allergic sensitization. This review focuses on the beneficial effects of food derived immunomodulating peptides on food allergy, which can be directly exerted in the intestinal tract or once being absorbed through the intestinal epithelial barrier to interact with immune cells. Food peptides influence intestinal homeostasis by maintaining and reinforcing barrier function or affecting intestinal cell-signalling to nearby immune cells and mucus secretion. In addition, they can stimulate cells of the innate and adaptive immune system while supressing inflammatory responses. Peptides represent an attractive alternative to whole allergens to enhance the safety and efficacy of immunotherapy treatments. The conclusions drawn from curative and preventive experiments in murine models are promising, although there is a need for more pre-clinical studies to further explore the immunomodulating strategy and its mechanisms and for a deeper knowledge of the peptide sequence and structural requirements that determine the immunoregulatory function.

中文翻译：

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用于食物过敏预防和治疗的免疫调节肽

当前针对IgE介导的过敏性疾病进行分析的最有希望的策略之一是，使用免疫调节肽来诱导对有害食物过敏原的口服耐受性，甚至预防过敏性致敏。这篇综述着重于食物衍生的免疫调节肽对食物过敏的有益作用，其可以直接在肠道中发挥作用，也可以通过肠道上皮屏障吸收后与免疫细胞相互作用。食物肽通过维持和增强屏障功能或影响肠细胞对附近免疫细胞和粘液分泌的信号传导来影响肠内稳态。此外，它们可以刺激先天性和适应性免疫系统的细胞，同时抑制炎症反应。肽代表了一种完整过敏原的诱人替代品，可增强免疫疗法的安全性和功效。尽管有必要开展更多的临床前研究来进一步探索免疫调节策略及其机制，并且需要更深入了解决定免疫调节作用的肽序列和结构要求，但从鼠类模型的治愈性和预防性实验中得出的结论是有希望的。功能。