A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy†,Materials Horizons

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A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy†
Materials Horizons ( IF 12.2 ) Pub Date : 2018-06-06 00:00:00 , DOI: 10.1039/c8mh00392k
Wenjun Li _{1,

2,

3,

4,

5} , Dongyuan Wang _{1,

2,

3,

4,

5} , Xiaodong Shi _{1,

2,

3,

4,

5} , Jingxu Li _{1,

2,

3,

4,

5} , Yue Ma _{1,

2,

3,

4,

5} , Yanding Wang _{1,

2,

3,

4,

5} , Tingting Li _{3,

4,

5,

6} , Jianing Zhang _{1,

2,

3,

4,

5} , Rongtong Zhao _{1,

2,

3,

4,

5} , Zhiqiang Yu _{5,

7,

8,

9,

10} , Feng Yin _{1,

2,

3,

4,

5} , Zigang Li _{1,

2,

3,

4,

5}

Affiliation

Herein, we report a unique siRNA-induced peptide co-assembly nanocarrier, which could efficiently co-assemble upon the addition of siRNA, forming nanospheres with high biocompatibility and transfection efficiency both in vitro and in vivo. In a tumor xenograft nude mouse model, these siRNA–peptide nanospheres inhibited tumor volume growth by >60%.

中文翻译：

siRNA诱导的肽共组装系统，作为基于肽的siRNA纳米载体，用于癌症治疗†

在本文中，我们报道了同时具有高生物相容性和转染效率的唯一siRNA诱导肽共组装纳米载体，当加入的siRNA可能有效共组装，形成纳米球在体外和体内。在肿瘤异种移植裸鼠模型中，这些siRNA-肽纳米球将肿瘤体积的生长抑制了60％以上。

更新日期：2018-06-06

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