Rationalization of Asymmetric Amplification via Autocatalysis Triggered by Isotopically Chiral Molecules,ACS Central Science

当前位置： X-MOL 学术 › ACS Cent. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Rationalization of Asymmetric Amplification via Autocatalysis Triggered by Isotopically Chiral Molecules
ACS Central Science ( IF 12.7 ) Pub Date : 2018-06-06 00:00:00 , DOI: 10.1021/acscentsci.8b00297
Neil A. Hawbaker ₁ , Donna G. Blackmond ₁

Affiliation

Asymmetric amplification induced in the Soai autocatalytic reaction by chiral initiators that are enantiomeric only by virtue of an isotope, e.g., −CH₃ vs CD₃–, is examined by spectroscopic, kinetic, and DFT modeling studies to help understand requirements for the emergence of biological homochirality. We find that the initiator inhibits the autocatalytic pathway at the outset of the reaction but ultimately provides the imbalance required for asymmetric amplification. This work provides clues in the ongoing search for prebiotically plausible versions of asymmetric autocatalysis.

中文翻译：

通过同位素手性分子引发的自催化的不对称扩增的合理化

通过光谱，动力学和DFT建模研究研究了仅通过同位素（例如-CH ₃ vs CD _3-）对映异构的手性引发剂在Soai自催化反应中诱导的不对称扩增，以帮助了解其出现的要求。生物学同质性。我们发现引发剂在反应开始时抑制了自身催化途径，但最终提供了不对称扩增所需的不平衡。这项工作为正在进行的不对称自动催化的益生元合理版本的寻找提供了线索。

更新日期：2018-06-06

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11