A series of benzofuran-2-carboxamide-N-benzyl pyridinium halide derivatives (6a-o) are synthesized as new cholinesterase inhibitors. The synthetic pathway involves the reaction of salicylaldehyde derivatives and ethyl bromoacetate, followed by hydrolysis and amidation with 3- and 4-picolyl amine. Subsequently, N-((pyridin-4-yl) methyl) benzofuran-2-carboxamide and substituted N-((pyridin-3-yl) methyl) benzofuran-2-carboxamides reacts with benzyl halides to afford target compounds (6a-o). The chemical structures of all derivatives were confirmed by spectroscopic methods. The studies reveal that some of the synthesized compounds are potent butyrylcholinesterase inhibitors with IC₅₀ values in the range of 0.054–2.7 µM. In addition, good inhibitory effects on Aβ self-aggregation are observed for 6h and 6k (33.1 and 46.4% at 100 µM, respectively).

合成了一系列苯并呋喃-2-羧酰胺-N-苄基吡啶鎓卤化物衍生物（6a-o）作为新型胆碱酯酶抑制剂。合成途径涉及水杨醛衍生物与溴乙酸乙酯的反应，然后水解并用3-和4-吡啶甲基胺进行酰胺化。随后，N -（（吡啶-4-基）甲基）苯并呋喃-2-甲酰胺和取代的N -（（吡啶-3-基）甲基）苯并呋喃-2-甲酰胺与苄基卤反应，得到目标化合物（6a-o ）。所有衍生物的化学结构通过光谱法确认。研究表明，某些合成的化合物是有效的丁酰胆碱酯酶抑制剂，IC ₅₀值在0.054–2.7 µM的范围内。此外，在6h和6k时观察到了对Aβ自聚集的良好抑制作用（在100 µM时分别为33.1％和46.4％）。