Tandem catalytic reaction in one-pot possesses remarkable advantages and is a powerful methodology for the synthesis of high value chemicals. Asymmetric transfer hydrogenation catalyzed by Ru-TsDPEN type catalysts, developed Noyori and Ikariya, is a useful strategy for constructing chiral alcohols and amines. Herein, a novel bifunctional Noyori-Ikariya type catalyst was developed, which displays good catalytic efficiency for Michael addition/ATH/cyclization tandem reaction. A series of chiral 3,4-dihydro-2H-pyran-5-carbonitriles were synthesized in good yield (up to 79%) and with excellent enantioselectivity (up to 97%) via this one-pot reaction under mild conditions.

一锅式串联催化反应具有显着优势，是合成高价值化学品的有力方法。由Noyori和Ikariya开发的Ru-TsDPEN型催化剂催化的不对称转移氢化是构建手性醇和胺的有用策略。在此，开发了一种新型的双官能Noyori-Ikariya型催化剂，其对迈克尔加成/ ATH /环化串联反应显示出良好的催化效率。通过在温和条件下的一锅反应，合成了一系列手性3,4-二氢-2 H-吡喃-5-腈，收率高（高达79％），对映选择性（高达97％）。