The current study deals with the synthesis of urea and thiourea derivatives 1–37 which were characterized by various spectroscopic techniques including FAB-MS, ¹H-, and ¹³C NMR. The synthetic compounds were subjected to urease inhibitory activity and compounds exhibited good to moderate urease inhibitory activity having IC₅₀ values in range of 10.11–69.80 µM. Compound 1 (IC₅₀ = 10.11 ± 0.11 µM) was found to be most active and even better as compared to the standard acetohydroxamic acid (IC₅₀ = 27.0 ± 0.5 µM). A limited structure–activity relationship (SAR) was established and the compounds were also subjected to docking studies to confirm the binding interactions of ligands (compounds) with the active site of enzyme.

与尿素的合成目前的研究优惠和硫脲衍生物1 - 37，其进行了表征通过各种光谱技术包括FAB-MS，¹ H-和¹³ C NMR。合成的化合物具有脲酶抑制活性，化合物表现出良好到中等的脲酶抑制活性，IC ₅₀值为10.11–69.80 µM。 与标准乙酰氧肟酸（IC _50）相比，化合物1（IC ₅₀ = 10.11±0.11 µM）具有最高的活性，甚至更好。 = 27.0±0.5 µM）。建立了有限的结构-活性关系（SAR），并对化合物也进行了对接研究，以确认配体（化合物）与酶的活性位点之间的结合相互作用。