The past decades in organic chemistry have witnessed significant improvements in synthetic efficiency as a result of considerable progress in cascade reactions, tandem reactions, and related one‐pot processes. These methods are less time‐consuming and produce less waste compared to the classical stepwise approach. However, cascade chemistry requires a more careful design and compatible reaction types for success. Palladium‐catalyzed cross‐coupling reactions, with their well understood multistep catalytic cycles, form a promising basis for the design of cascade reactions. Furthermore, they are compatible with a range of functional groups and can be combined with a range of secondary transformations. The resulting palladium‐catalyzed cascade reactions have provided access to a plethora of complex small molecules of high medicinal relevance. This review provides an overview of the developments in palladium‐catalyzed cascade reactions since 2011, classified according to the initiation, propagation, and termination steps comprising the palladium cascade reactions. This classification should assist the reader and may provide inspiration for the design of new cascade reactions.

中文翻译：

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钯催化级联环化研究进展

由于级联反应，串联反应和相关的一锅法技术取得了长足的进步，过去几十年来有机化学已见证了合成效率的显着提高。与传统的逐步方法相比，这些方法耗时少，浪费少。但是，级联化学需要更仔细的设计和兼容的反应类型才能成功。钯催化的交叉偶联反应及其众所周知的多步催化循环，为级联反应的设计奠定了有希望的基础。此外，它们与一系列官能团相容并且可以与一系列二次转化结合。由此产生的钯催化的级联反应使人们可以接触到许多具有高度医学相关性的复杂小分子。这篇综述概述了自2011年以来钯催化的级联反应的发展情况，并根据包括钯级联反应的引发，扩散和终止步骤进行了分类。这种分类应有助于读者，并可以为设计新的级联反应提供启发。