Scalable production of double emulsion drops with thin shells†,Lab on a Chip

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Scalable production of double emulsion drops with thin shells†
Lab on a Chip ( IF 6.1 ) Pub Date : 2018-06-05 00:00:00 , DOI: 10.1039/c8lc00282g
A. Vian _{1,

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5} , B. Reuse _{1,

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Affiliation

Double emulsions are often used as containers to perform high throughput screening assays and as templates for capsules. These applications require double emulsions to be mechanically stable such that they do not coalesce during processing and storage. A possibility to increase their stability is to reduce the thickness of their shells to sufficiently low values that lubrication effects hinder coalescence. However, the controlled fabrication of double emulsions with such thin shells is difficult. Here, we introduce a new microfluidic device, the aspiration device, that reduces the shell thickness of double emulsions down to 240 nm at a high throughput; thereby, the shell volume is reduced by up to 95%. The shell thickness of the resulting double emulsions depends on the pressure profile in the device and hence on the fluid flow rates in the channels and is independent of the shell thickness of the injected double emulsions. Therefore, this device enables converting double emulsions with polydisperse shell thicknesses into double emulsions with well-defined, uniform thin shells.

中文翻译：

具有薄壳的双乳液滴剂的可扩展生产†

双重乳剂通常用作执行高通量筛选分析的容器，以及用作胶囊的模板。这些应用要求双重乳液在机械上是稳定的，以使其在加工和储存期间不会聚结。增加其稳定性的一种可能性是将其壳的厚度减小到足够低的值，以至于润滑作用阻碍了聚结。但是，用这种薄壳来控制双乳液的制造是困难的。在这里，我们介绍了一种新的微流控装置，即抽吸装置，该装置可以以高通量将双乳状液的壳厚度降低至240 nm。因此，外壳体积最多可减少95％。所得双乳剂的壳厚度取决于装置中的压力曲线，并因此取决于通道中的流体流速，并且与所注入的双乳剂的壳厚度无关。因此，该装置能够将具有多分散壳厚度的双重乳液转变为具有清晰，均匀的薄壳的双重乳液。

更新日期：2018-06-05

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