Recent Progress in Macromolecule‐Anchored Hybrid Gold Nanomaterials for Biomedical Applications,Macromolecular Rapid Communications

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Recent Progress in Macromolecule‐Anchored Hybrid Gold Nanomaterials for Biomedical Applications
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2018-06-04 , DOI: 10.1002/marc.201800029
Zheng Luo ₁ , Yang Xu ₁ , Enyi Ye ₂ , Zibiao Li ₂ , Yun-Long Wu ₁

Affiliation

Gold nanoparticles (AuNPs), with elegant thermal, optical, or chemical properties due to quantum size effects, may serve as unique species for therapeutic or diagnostic applications. It is worth mentioning that their small size also results in high surface activity, leading to significantly impaired stability, which greatly hinders their biomedical utilizations. To overcome this problem, various types of macromolecular materials are utilized to anchor AuNPs so as to achieve advanced synergistic effect by dispersing, protecting, and stabilizing the AuNPs in polymeric–Au hybrid self‐assemblies. In this review, the most recent development of polymer–AuNP hybrid systems, including AuNPs@polymeric nanoparticles, AuNPs@polymeric micelle, AuNPs@polymeric film, and AuNPs@polymeric hydrogel are discussed with respect to their different synthetic strategies. These sophisticated materials with diverse functions, oriented toward biomedical applications, are further summarized into several active domains in the areas of drug delivery, gene delivery, photothermal therapy, antibacterials, bioimaging, etc. Finally, the possible approaches for future design of multifunctional polymer–AuNP hybrids by combining hybrid chemistry with biological interface science are proposed.

中文翻译：

用于生物医学的大分子固定杂化金纳米材料的最新进展

金纳米颗粒（AuNPs）由于量子尺寸效应而具有出色的热，光学或化学特性，可作为治疗或诊断应用的独特物种。值得一提的是，它们的小尺寸也导致其高表面活性，从而导致稳定性显着受损，从而极大地阻碍了其生物医学利用。为了克服这个问题，可以使用各种类型的高分子材料固定AuNP，从而通过分散，保护和稳定Au-NP在聚合物-Au混合自组装物中达到先进的协同作用。在这篇综述中，讨论了聚合物-AuNP杂化系统的最新发展，包括AuNPs @聚合物纳米颗粒，AuNPs @聚合物胶束，AuNPs @聚合物膜和AuNPs @聚合物水凝胶的不同合成策略。

更新日期：2018-06-04

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