We recently reported that tetraphenylethene-appended poly(acrylic acid) derivatives (e.g., PAA-TPE_0.02) can serve as fluorescent Ca²⁺ sensors in the presence of physiological concentrations of biologically relevant ions, amino acids, and sugars. However, in the presence of basic proteins such as albumins, the Ca²⁺-sensing property of the polymer is significantly impaired due to the nonspecific adsorption of protein molecules, which competes with binding to Ca²⁺. To solve this problem, we explored new designs by focusing on the polymer-chain topology of PAA-TPE_0.02 with biocompatible segments. Here, we report the Ca²⁺-sensing and protein-adsorption-resistance properties of various types of PAA-TPE_0.02 copolymers with a poly(oligoethylene glycol acrylate) (polyOEGA) segment, featuring a random, diblock, triblock, or 4-armed-star-block structure. Through this study, we show an interesting topology effect; i.e., a branch-shaped PAA-TPE_0.02-co-polyOEGA with biocompatible segments at every terminal (i.e., 4-armed-star-block copolymer) exhibits both good Ca²⁺-sensing and protein-adsorption-resistance properties.

中文翻译：

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具有生物相容性链段的 AIEgen 附加聚丙烯酸对 Ca2+ 传感和蛋白质抗吸附性能的拓扑影响

我们最近报道了在生理浓度的生物相关离子、氨基酸和糖存在的情况下，四苯基乙烯附加的聚（丙烯酸）衍生物（例如，PAA-TPE _0.02）可以用作荧光 Ca ^{2+传感器。}然而，在白蛋白等碱性蛋白质存在的情况下，由于蛋白质分子的非特异性吸附与与Ca 2+ 的结合竞争，聚合物的Ca ²⁺感应特性显着^受损。为了解决这个问题，我们通过关注具有生物相容性片段的 PAA-TPE _{0.02的聚合物链拓扑结构来探索新的设计。}在这里，我们报告 Ca ²⁺-具有无规、二嵌段、三嵌段或四臂星形嵌段结构的聚（低聚乙二醇丙烯酸酯）（polyOEGA）链段的各种类型 PAA-TPE _{0.02共聚物的传感和抗蛋白质吸附性能。}通过这项研究，我们展示了一种有趣的拓扑效应；即，在每个末端具有生物相容性链段的分支形PAA-TPE _0.02-共聚OEGA（即，4-臂-星形-嵌段共聚物）表现出良好的Ca 2+^感应和蛋白质吸附抗性。