Bioorthogonally Applicable Fluorescence Deactivation Strategy for Receptor Kinetics Study and Theranostic Pretargeting Approaches,ChemBioChem

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Bioorthogonally Applicable Fluorescence Deactivation Strategy for Receptor Kinetics Study and Theranostic Pretargeting Approaches
ChemBioChem ( IF 2.6 ) Pub Date : 2018-07-10 , DOI: 10.1002/cbic.201800229
Steffen van der Wal ₁ , Clarize M de Korne ₁ , Laurens G L Sand _{2,

3} , Danny M van Willigen ₁ , Pancras C W Hogendoorn ₂ , Karoly Szuhai ₄ , Fijs W B van Leeuwen ₁ , Tessa Buckle _{1,

5}

Affiliation

Membrane receptor bioimaging: A new screening method for application of membrane receptors in (pre‐)targeted theranostics, based on click chemistry and deactivatable fluorescence quenching, has been developed and used to achieve discrimination between the membranous and internalized receptor fractions through quantitative assessment of quenching/internalization kinetics.