A bulky carboxylic acid bearing three cyclohexylmethyl substituents at the α‐position, namely, tri(cyclohexylmethyl)acetic acid, is demonstrated to act as an efficient ligand source in Pd‐catalyzed intramolecular C(sp²)−H and C(sp³)−H arylation reactions. The reactions proceed smoothly under mild reaction conditions, even at room temperature due to the steric bulk of the carboxylate ligands, which accelerates the rate‐determining C−H bond activation step in the catalytic cycle.

中文翻译：

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羧酸盐配体对钯催化的分子内C（sp2）–H和C（sp3）–H芳基化反应的立体效应

在α-位置带有三个环己基甲基取代基的大分子羧酸，即三（环己基甲基）乙酸被证明是Pd催化的分子内C（sp ²）-H和C（sp ³）的有效配体来源-H芳基化反应。由于羧酸盐配体的空间体积较大，即使在室温下，反应也可在温和的反应条件下顺利进行，这加快了催化循环中确定C H键活化步骤的速度。