Dimeric BODIPY-loaded liposomes for dual hypoxia marker imaging and activatable photodynamic therapy against tumors†,Journal of Materials Chemistry B

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Dimeric BODIPY-loaded liposomes for dual hypoxia marker imaging and activatable photodynamic therapy against tumors†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-06-04 00:00:00 , DOI: 10.1039/c8tb00665b
Huachao Chen _{1,

2,

3,

4,

5} , Qirui Bi _{1,

2,

3,

4,

5} , Yongrong Yao _{1,

2,

3,

4,

5} , Ninghua Tan _{1,

2,

3,

4,

5}

Affiliation

This work reports a dimeric BODIPY (BDP)-loaded liposome with conjugation of anti-HIF antibodies for dual hypoxia marker imaging and nitroreductase (NTR)-activatable photodynamic therapy (PDT) against hypoxic tumors. In this theranostic nanosystem (designated Ab-DiBDP NPs), the newly designed orthogonal BDP dimer has high ¹O₂ quantum yield, and the substitution of a nitro group at the meso-position leads to the NTR-controllable activation of phototoxicity and fluorescence. Both in vivo and in vitro experiments demonstrate that the NTR-activatable PDT liposome can efficiently destroy cancer cells and prevent damage to normal cells. More significantly, the fascinating advantage of the nanoprobe is the synergy between the Cy 7-marked anti-HIF-1α antibody and the NTR-activatable DiBDP, which significantly improves the accuracy of tumor hypoxia imaging by simultaneous detection of NTR and HIF-1α. Therefore, this work presents a new paradigm for NTR-triggered PDT against cancer cells and provides a new avenue for precise tumor hypoxia diagnosis.

中文翻译：

装有二聚体BODIPY的脂质体可用于双重缺氧标记物成像和可激活的光动力疗法，以治疗肿瘤†

这项工作报告了二聚体BODIPY（BDP）负载的脂质体与抗HIF抗体的缀合，用于双重缺氧标记物成像和可对缺氧肿瘤进行硝化还原酶（NTR）激活的光动力疗法（PDT）。在这种治疗诊断纳米系统（指定的Ab-DiBDP NPS），新设计的正交BDP二聚体具有高¹ Ò ₂量子产率，和硝基的在取代内消旋-位导致光毒性和荧光的NTR-可控活化。两者在体内和体外实验证明，可激活NTR的PDT脂质体可有效破坏癌细胞并防止对正常细胞的破坏。更重要的是，纳米探针的引人入胜的优势是Cy 7标记的抗HIF-1α抗体与可激活NTR的DiBDP之间的协同作用，可通过同时检测NTR和HIF-1α显着提高肿瘤缺氧成像的准确性。因此，这项工作为NTR触发的PDT对癌细胞提出了新的范例，并为精确的肿瘤缺氧诊断提供了新的途径。

更新日期：2018-06-04

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