A biomimetic hierarchical structure with a hydrophilic surface and a hydrophobic subsurface constructed from waterborne polyurethanes containing a self-assembling peptide extender†,Journal of Materials Chemistry B

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A biomimetic hierarchical structure with a hydrophilic surface and a hydrophobic subsurface constructed from waterborne polyurethanes containing a self-assembling peptide extender†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-06-04 00:00:00 , DOI: 10.1039/c8tb01279b
Fanjun Zhang _{1,

2,

3,

4,

5} , Rong Wang _{1,

2,

3,

4,

5} , Yuanyuan He _{1,

2,

3,

4,

5} , Weiwei Lin _{1,

2,

3,

4,

5} , Yuxi Li _{1,

2,

3,

4,

5} , Yiqi Shao _{1,

2,

3,

4,

5} , Jiehua Li _{1,

2,

3,

4,

5} , Mingming Ding _{1,

2,

3,

4,

5} , Feng Luo _{1,

2,

3,

4,

5} , Hong Tan _{1,

2,

3,

4,

5} , Qiang Fu _{1,

2,

3,

4,

5}

Affiliation

Constructing a biomimetic hierarchical structure is of great benefit to achieve materials with expected high performance. In this work, a new Fmoc-diphenylalanine (Fmoc-FF) based peptide extender (PPE) is synthesized for preparing a series of waterborne polyurethanes (WPUs) to construct a hydrophilic surface and a hydrophobic subsurface. A pre-assembly structure of the WPU emulsion particle is achieved by the introduction of PPE. It possesses a compact core consisting of hydrophobic segments of Fmoc-FF with π–π stacking and a loose shell consisting of hydrophilic polyethylene glycol (PEG) segments. The self-assembled Fmoc-FF could also enhance the phase separation between soft segments and hard segments. During film formation by demulsification, the outer PEG segments easily migrate onto the surface and the hydrophobic compact cores aggregate into the subsurface. Such an architecture endows WPU films with simultaneous biocompatibility, antifouling ability, and water resistance under wet conditions. This work provides a new insight into the design of a polymer emulsion with a pre-assembled phase to construct the expected hierarchical structure of films or coatings for biomaterials and antifouling materials.

中文翻译：

由亲水性表面和疏水性次表面组成的仿生分层结构，该结构由包含自组装肽增量剂的水性聚氨酯构成†

构建仿生层级结构对获得具有预期高性能的材料非常有好处。在这项工作中，合成了一种新的基于Fmoc-二苯丙氨酸（Fmoc-FF）的肽扩展剂（PPE），用于制备一系列水性聚氨酯（WPU），以构建亲水性表面和疏水性次表面。WPU乳液颗粒的预组装结构是通过引入PPE来实现的。它具有由Fmoc-FF的疏水链段和π–π堆积组成的紧凑型核，以及由亲水性聚乙二醇（PEG）链段组成的松散壳。自组装的Fmoc-FF还可以增强软链段和硬链段之间的相分离。在通过破乳形成膜的过程中，外部PEG片段很容易迁移到表面上，而疏水性紧密核聚集到地下。这种结构赋予WPU膜在湿润条件下同时具有生物相容性，防污能力和耐水性。这项工作为具有预组装阶段的聚合物乳液的设计提供了新的见解，以构建用于生物材料和防污材料的薄膜或涂层的预期分层结构。

更新日期：2018-06-04

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