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Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots for in vivo HER-2 receptor-targeted imaging†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-06-04 00:00:00 , DOI: 10.1039/c8cc03037e Yayun Wu 1, 2, 3, 4, 5 , Zhizhen Chen 6, 7, 8, 9, 10 , Pengfei Zhang 1, 2, 3, 4, 5 , Lihua Zhou 1, 2, 3, 4, 5 , Tao Jiang 1, 2, 3, 4, 5 , Huajie Chen 11, 12, 13, 14, 15 , Ping Gong 1, 2, 3, 4, 5 , Dimiter S. Dimitrov 16, 17, 18, 19 , Lintao Cai 1, 2, 3, 4, 5 , Qi Zhao 6, 7, 8, 9, 10
Chemical Communications ( IF 4.3 ) Pub Date : 2018-06-04 00:00:00 , DOI: 10.1039/c8cc03037e Yayun Wu 1, 2, 3, 4, 5 , Zhizhen Chen 6, 7, 8, 9, 10 , Pengfei Zhang 1, 2, 3, 4, 5 , Lihua Zhou 1, 2, 3, 4, 5 , Tao Jiang 1, 2, 3, 4, 5 , Huajie Chen 11, 12, 13, 14, 15 , Ping Gong 1, 2, 3, 4, 5 , Dimiter S. Dimitrov 16, 17, 18, 19 , Lintao Cai 1, 2, 3, 4, 5 , Qi Zhao 6, 7, 8, 9, 10
Affiliation
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We developed highly bright and stable far-red emissive AIEdots by using a new kind of click-functional PEG grafted amphiphilic polymer to coat hydrophobic AIE-active polymers (PDFDP). Furthermore, an anti-HER2 recombinant fully human antibody was produced and conjugated on the AIEdots via metal-free click chemistry to fabricate in vivo tumor-targeting nanoprobes.
中文翻译：
重组人抗体修饰的高度稳定的远红色AIEdot，用于体内HER-2受体靶向成像†
通过使用新型的单击功能PEG接枝的两亲聚合物来涂覆疏水性AIE活性聚合物（PDFDP），我们开发了高亮度和稳定的远红外发射性AIEdot。此外，产生了抗HER2重组完全人类抗体，并通过无金属点击化学将其缀合在AIEdots上，以制备体内靶向肿瘤的纳米探针。
更新日期：2018-06-04
中文翻译：
重组人抗体修饰的高度稳定的远红色AIEdot，用于体内HER-2受体靶向成像†
通过使用新型的单击功能PEG接枝的两亲聚合物来涂覆疏水性AIE活性聚合物（PDFDP），我们开发了高亮度和稳定的远红外发射性AIEdot。此外，产生了抗HER2重组完全人类抗体，并通过无金属点击化学将其缀合在AIEdots上，以制备体内靶向肿瘤的纳米探针。
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