Biocompatible and Biodegradable Fe3+–Melanoidin Chelate as a Potentially Safe Contrast Agent for Liver MRI,Bioconjugate Chemistry

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Biocompatible and Biodegradable Fe3+–Melanoidin Chelate as a Potentially Safe Contrast Agent for Liver MRI
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2018-06-01 00:00:00 , DOI: 10.1021/acs.bioconjchem.8b00331
Min-Young Lee _{1,

2} , Dongil Choi _{1,

2,

3} , Moon-Sun Jang _{2,

3} , Jung Hee Lee _{2,

3}

Affiliation

Currently, most MRI probes available for clinical use contain gadolinium, which is a high-risk paramagnetic metal that can cause severe side effects (e.g., nephrogenic systemic fibrosis). To limit such side effects and improve diagnostic efficacy, we developed a novel biocompatible MRI contrast agent using glucose, glycine, and paramagnetic iron ion. Glucose and glycine were polymerized into melanoidin by the nonenzymatic Maillard reaction, and Fe³⁺ was chelated stably with the melanoidin during polymerization. The Fe³⁺–melanoidin chelate had biocompatibility, biodegradability, and unique contrast effects on both T₁- and T₂-weighted MRI, depending on the pH and oxidative environments. The administration of the Fe³⁺–melanoidin chelate to a mouse model of liver cancer showed highly enhanced liver-to-tumor contrasts on both T₁- and T₂-weighted MRI.

中文翻译：

具有生物相容性和可生物降解性的Fe ^{3+ –}黑色素螯合物作为肝脏MRI的潜在安全对比剂

当前，大多数可用于临床的MRI探针都含有g，is是一种高风险的顺磁性金属，会引起严重的副作用（例如，肾原性系统性纤维化）。为了限制此类副作用并提高诊断效率，我们开发了一种使用葡萄糖，甘氨酸和顺磁性铁离子的新型生物相容性MRI造影剂。葡萄糖和甘氨酸通过非酶促美拉德反应聚合成黑色素，并且在聚合过程中Fe ³⁺与黑色素稳定地螯合。Fe ^{3+ –}黑色素螯合物对T ₁和T ₂加权MRI具有生物相容性，生物降解性和独特的对比作用，具体取决于pH和氧化环境。Fe ³⁺的给药–黑色素螯合剂对肝癌小鼠模型在T ₁和T ₂加权MRI上均显示肝脏与肿瘤的对比大大增强。

更新日期：2018-06-01

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