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Biocompatible and Biodegradable Fe3+–Melanoidin Chelate as a Potentially Safe Contrast Agent for Liver MRI
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2018-06-01 00:00:00 , DOI: 10.1021/acs.bioconjchem.8b00331
Min-Young Lee 1, 2 , Dongil Choi 1, 2, 3 , Moon-Sun Jang 2, 3 , Jung Hee Lee 2, 3
Affiliation  

Currently, most MRI probes available for clinical use contain gadolinium, which is a high-risk paramagnetic metal that can cause severe side effects (e.g., nephrogenic systemic fibrosis). To limit such side effects and improve diagnostic efficacy, we developed a novel biocompatible MRI contrast agent using glucose, glycine, and paramagnetic iron ion. Glucose and glycine were polymerized into melanoidin by the nonenzymatic Maillard reaction, and Fe3+ was chelated stably with the melanoidin during polymerization. The Fe3+–melanoidin chelate had biocompatibility, biodegradability, and unique contrast effects on both T1- and T2-weighted MRI, depending on the pH and oxidative environments. The administration of the Fe3+–melanoidin chelate to a mouse model of liver cancer showed highly enhanced liver-to-tumor contrasts on both T1- and T2-weighted MRI.

中文翻译:

具有生物相容性和可生物降解性的Fe 3+ –黑色素螯合物作为肝脏MRI的潜在安全对比剂

当前,大多数可用于临床的MRI探针都含有g,is是一种高风险的顺磁性金属,会引起严重的副作用(例如,肾原性系统性纤维化)。为了限制此类副作用并提高诊断效率,我们开发了一种使用葡萄糖,甘氨酸和顺磁性铁离子的新型生物相容性MRI造影剂。葡萄糖和甘氨酸通过非酶促美拉德反应聚合成黑色素,并且在聚合过程中Fe 3+与黑色素稳定地螯合。Fe 3+ –黑色素螯合物对T 1和T 2加权MRI具有生物相容性,生物降解性和独特的对比作用,具体取决于pH和氧化环境。Fe 3+的给药–黑色素螯合剂对肝癌小鼠模型在T 1和T 2加权MRI上均显示肝脏与肿瘤的对比大大增强。
更新日期:2018-06-01
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