Robust Thin Film Surface with a Selective Antibacterial Property Enabled via a Cross-Linked Ionic Polymer Coating for Infection-Resistant Medical Applications,ACS Biomaterials Science & Engineering

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Robust Thin Film Surface with a Selective Antibacterial Property Enabled via a Cross-Linked Ionic Polymer Coating for Infection-Resistant Medical Applications
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2018-06-01 00:00:00 , DOI: 10.1021/acsbiomaterials.8b00241
Goro Choi ₁ , Gu Min Jeong ₁ , Myung Seok Oh ₁ , Munkyu Joo ₁ , Sung Gap Im ₁ , Ki Jun Jeong ₁ , Eunjung Lee ₁

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Fabrication of new antibacterial surfaces has become a primary strategy for preventing device-associated infections (DAIs). Although considerable progress has recently been made in reducing DAIs, current antibacterial coating methods are technically complex and do not allow selective bacterial killing. Here, we propose novel anti-infective surfaces made of a cross-linked ionic polymer film that achieve selective bacteria killing while simultaneously favoring the survival of mammalian cells. A one-step polymerization process known as initiated chemical vapor deposition was used to generate a cross-linked ionic polymer film from 4-vinylbenzyl chloride and 2-(dimethylamino) ethyl methacrylate monomers in the vapor phase. In particular, the deposition process produced a polymer network with quaternary ammonium cross-linking sites, which provided the surface with an ionic moiety with an excellent antibacterial contact-killing property. This method confers substrate compatibility, which enables various materials to be coated with ionic polymer films for use in medical implants. Moreover, the ionic polymer-deposited surfaces supported the healthy growth of mammalian cells while selectively inhibiting bacterial growth in coculture models without any detectable cytotoxicity. Thus, the cross-linked ionic polymer-based antibacterial surface developed in this study can serve as an ideal platform for biomedical applications that require a highly sterile environment.

中文翻译：

通过交联离子聚合物涂层实现的具有选择性抗菌特性的坚固薄膜表面，可用于抗感染的医疗应用

制造新的抗菌表面已成为预防设备相关感染（DAI）的主要策略。尽管最近在减少DAIs方面已取得了相当大的进步，但是当前的抗菌包衣方法在技术上很复杂，不能选择性杀灭细菌。在这里，我们提出了一种由交联的离子聚合物薄膜制成的新型抗感染表面，该表面可实现选择性杀灭细菌，同时有利于哺乳动物细胞的存活。一步聚合法被称为引发化学气相沉积法，用于在气相中由4-乙烯基苄基氯和甲基丙烯酸2-（二甲氨基）乙基酯单体生成交联的离子聚合物薄膜。具体而言，沉积过程产生了具有季铵交联位点的聚合物网络，它为表面提供了离子基团，该离子基团具有出色的抗菌接触杀伤性能。该方法赋予基底相容性，其使得各种材料可以用离子聚合物膜涂覆以用于医疗植入物。此外，离子聚合物沉积的表面支持哺乳动物细胞的健康生长，同时在共培养模型中选择性抑制细菌生长而没有任何可检测的细胞毒性。因此，本研究开发的基于交联离子聚合物的抗菌表面可作为需要高度无菌环境的生物医学应用的理想平台。这使各种材料都可以用离子聚合物薄膜涂覆，以用于医疗植入物。此外，离子聚合物沉积的表面支持哺乳动物细胞的健康生长，同时在共培养模型中选择性抑制细菌生长而没有任何可检测的细胞毒性。因此，本研究开发的基于交联离子聚合物的抗菌表面可作为需要高度无菌环境的生物医学应用的理想平台。这使各种材料都可以用离子聚合物薄膜涂覆，以用于医疗植入物。此外，离子聚合物沉积的表面支持哺乳动物细胞的健康生长，同时在共培养模型中选择性抑制细菌生长而没有任何可检测的细胞毒性。因此，本研究开发的基于交联离子聚合物的抗菌表面可作为需要高度无菌环境的生物医学应用的理想平台。

更新日期：2018-06-01

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