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Studies directed toward the asialoglycoprotein receptor mediated delivery of 5-fluoro-2′-deoxyuridine for hepatocellular carcinoma
Bioorganic & Medicinal Chemistry Letters ( IF 2.7 ) Pub Date : 2018-06-01 , DOI: 10.1016/j.bmcl.2018.06.002 Lorena Rico , Michael E. Østergaard , Melanie Bell , Punit P. Seth , Stephen Hanessian
中文翻译：
针对脱唾液酸糖蛋白受体介导的5-氟-2'-脱氧尿苷肝细胞癌的研究
更新日期：2018-06-01
Bioorganic & Medicinal Chemistry Letters ( IF 2.7 ) Pub Date : 2018-06-01 , DOI: 10.1016/j.bmcl.2018.06.002 Lorena Rico , Michael E. Østergaard , Melanie Bell , Punit P. Seth , Stephen Hanessian
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The anticancer nucleoside 5-fluoro 2′-deoxyuridine-5′-phosphate (5-FdU-P) was attached via an amide chain linker to a triantennary GalNAc cluster as a means to deliver the drug to hepatic cells that recognize the amino sugar units.
中文翻译：
针对脱唾液酸糖蛋白受体介导的5-氟-2'-脱氧尿苷肝细胞癌的研究
抗癌核苷5-氟2'-脱氧尿苷-5'-磷酸（5-FdU-P）通过酰胺链接头连接到三天线GalNAc簇上，作为将药物递送到识别氨基糖单元的肝细胞的一种手段。
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