NMR Relaxometry to Characterize the Drug Structural Phase in a Porous Construct,Molecular Pharmaceutics

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NMR Relaxometry to Characterize the Drug Structural Phase in a Porous Construct
Molecular Pharmaceutics ( IF 4.5 ) Pub Date : 2018-06-01 00:00:00 , DOI: 10.1021/acs.molpharmaceut.8b00144
Linn W. Thrane _{1,

2} , Emily A. Berglund ₁ , James N. Wilking ₁ , David Vodak ₃ , Joseph D. Seymour ₁

Affiliation

Nuclear magnetic resonance (NMR) frequency spectra and T₂ relaxation time measurements, using a high-power radio frequency probe, are shown to characterize the presence of an amorphous drug in a porous silica construct. The results indicate the ability of non-solid-state NMR methods to characterize crystalline and amorphous solid structural phases in drugs. Two-dimensional T₁–T₂ magnetic relaxation time correlation experiments are shown to monitor the impact of relative humidity on the drug in a porous silica tablet.

中文翻译：

核磁共振弛豫法表征多孔结构中的药物结构相

使用大功率射频探头显示的核磁共振（NMR）频谱和T ₂弛豫时间测量表明了多孔二氧化硅结构中无定形药物的存在。结果表明非固态NMR方法能够表征药物中的结晶和无定形固体结构相。二维T ₁ - T ₂磁弛豫时间相关性实验表明，可以监测相对湿度对多孔二氧化硅片剂中药物的影响。

更新日期：2018-06-01

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