Gene-based therapies represent a promising therapeutic paradigm for the treatment of HIV-1, as they have the potential to maintain sustained viral inhibition with reduced treatment interventions. Such an option may represent a long-term treatment alternative to highly active antiretroviral therapy.

中文翻译：

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HIV-1受体靶向的适体-siRNA共轭物指导的转录调控

基于基因的疗法代表了治疗HIV-1的有前途的治疗范例，因为它们有可能通过减少干预措施来维持持续的病毒抑制作用。这种选择可能代表了高活性抗逆转录病毒疗法的长期治疗替代方案。