Photodynamic therapy (PDT) holds promise for focal therapy of prostate cancer (PCa). However, the therapeutic efficacy needs improvement, and further development of PDT for PCa has challenges, including uncertainty of photosensitizers (PSs) accumulation at the tumor site and difficulty in visualizing lesions using conventional ultrasound (US) imaging. We have developed novel porphyrin-grafted lipid (PGL) microbubbles (MBs; PGL-MBs) and propose a strategy to integrate PGL-MBs with US imaging to address these limitations and enhance PDT efficacy.

中文翻译：

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卟啉嫁接的脂质微泡通过超声控制的原位累积增强前列腺癌光动力疗法的功效。

光动力疗法（PDT）有望用于前列腺癌（PCa）的局部治疗。然而，治疗功效需要提高，并且PCa的PDT的进一步开发面临挑战，包括不确定光敏剂（PSs）在肿瘤部位的蓄积以及难以使用常规超声（US）成像可视化病变。我们已经开发了新颖的卟啉接枝脂质（PGL）微泡（MBs; PGL-MBs），并提出了将PGL-MBs与美国成像技术整合的策略，以解决这些局限性并增强PDT的功效。