The ability to identify metabolically active and potentially salvageable ischaemic penumbra is crucial for improving treatment decisions in acute stroke patients. Our solution involves two complementary novel MRI techniques (Glasgow Oxygen Level Dependant (GOLD) Metabolic Imaging), which when combined with a perfluorocarbon (PFC) based oxygen carrier and hyperoxia can identify penumbra due to dynamic changes related to continued metabolism within this tissue compartment. Our aims were (i) to investigate whether PFC offers similar enhancement of the second technique (Lactate Change) as previously demonstrated for the T₂*OC technique (ii) to demonstrate both GOLD metabolic imaging techniques working concurrently to identify penumbra, following administration of Oxycyte^® (O-PFC) with hyperoxia.

中文翻译：

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全氟化碳增强的格拉斯哥血氧依赖水平（GOLD）磁共振代谢成像可识别急性缺血性卒中后的半影

识别代谢活跃和潜在可挽救的缺血性半影​​的能力对于改善急性中风患者的治疗决策至关重要。我们的解决方案涉及两种互补的新颖MRI技术（格拉斯哥血氧依赖水平（GOLD）代谢成像），当与基于全氟化碳（PFC）的氧气载体和高氧结合使用时，由于与该组织室内持续代谢相关的动态变化，可以识别半影。我们的目的是（i）研究PFC是否对第二种技术（乳酸变化）的增强作用与先前对T ₂ * OC技术的证明相类似（ii）证明两种金代谢成像技术可同时用于鉴定半影氧气^® （O-PFC）与高氧血症。