The ability of cancers to evade conventional treatments, such as chemotherapy and radiation therapy, has been attributed to a subpopulation of cancer stem cells (CSCs). CSCs are regulated by mechanisms similar to those that regulate normal stem cells (NSCs), including processes involving ubiquitination and deubiquitination enzymes (DUBs) that regulate the expression of various factors, such as Notch, Wnt, Sonic Hedgehog (Shh), and Hippo. In this review, we discuss the roles of various DUBs involved in the regulation of core stem cell transcription factors and CSC-related proteins that are implicated in the modulation of cellular processes and carcinogenesis. In addition, we discuss the various DUB inhibitors that have been designed to target processes relevant to cancer and CSC maintenance.

癌症逃避常规疗法（例如化学疗法和放射疗法）的能力已归因于癌症干细胞（CSC）的亚群。CSCs的调控机制与调控正常干细胞（NSCs）的机制相似，包括涉及泛素化和去泛素化酶（DUBs）的过程，这些酶调控各种因子（例如Notch，Wnt，Sonic Hedgehog（Shh）和Hippo）的表达。在这篇综述中，我们讨论了参与调控核心干细胞转录因子和CSC相关蛋白的各种DUB的作用，这些因子与细胞过程的调节和致癌作用有关。此外，我们讨论了旨在针对与癌症和CSC维持相关的过程的各种DUB抑制剂。