Bisphenol A (BPA) and Di-(2-ethylhexyl) phthalate (DEHP) are two wide spread chemicals classified as endocrine disruptors (ED). The present study aims to estimate the non-dietary (dermal, non-dietary ingestion and inhalation) exposure to BPA and DEHP for a pregnant women cohort. In addition, to assess the prenatal exposure for the fetus, a physiologically based pharmacokinetic (PBPK) model was used. It was adapted for pregnancy in order to assess the internal dosimetry levels of EDs (BPA and DEHP) in the fetus. Estimates of exposure to BPA and DEHP from all pathways along with their relative importance were provided in order to establish which proportion of the total exposure came from diet and which came from non-dietary exposures. In this study, the different oral dosing scenarios (dietary and non-dietary) were considered keeping inhalation as a continuous exposure case. Total non-dietary mean values were 0.002 µg/kg_bw/day (0.000; 0.004 µg/kg_bw/day for 5th and 95th percentile, respectively) for BPA and 0.597 µg/kg_bw/day (0.116 µg/kg_bw/day and 1.506 µg/kg_bw/day for 5th and 95th percentile, respectively) for DEHP. Indoor environments and especially dust ingestion were the main non-dietary contributors to the total exposure of BPA and DEHP with 60% and 81%. However, as expected, diet showed the higher contribution to total exposure with > 99.9% for BPA and 63% for DEHP. Although diet was considered the primary source of exposure to BPA and phthalates, it must be taken into account that with non-dietary sources the first-pass metabolism is lacking, so these may be of equal or even higher toxicological relevance than dietary sources.

The present study is in the framework of “Health and environmental-wide associations based on large population surveys” (HEALS) project (FP7–603946).

双酚A（BPA）和邻苯二甲酸二-（2-乙基己基）酯（DEHP）是被广泛分类为内分泌干扰物（ED）的两种化学品。本研究旨在评估孕妇队列中非饮食（皮肤，非饮食摄入和吸入）对BPA和DEHP的暴露。另外，为了评估胎儿的产前暴露，使用了基于生理学的药代动力学（PBPK）模型。它适用于妊娠，以评估胎儿体内EDs（BPA和DEHP）的内部剂量水平。提供了所有途径对BPA和DEHP的暴露量及其相对重要性的估算，以便确定在总暴露量中哪个比例来自饮食，哪个比例来自非饮食暴露。在这项研究中，不同的口服剂量方案（饮食和非饮食）被认为是连续吸入的情况下保持吸入。非饮食总平均值为0.002 µg / kg_bw /天（对于BPA为0.000；对于第5个百分位数为0.004 µg / kg _bw /天；对于第5个百分位数为0.597 µg / kg _bw /天（对于第5个百分位数，为0.116 µg / kg _bw /天； 1.506 µg / kg _bw /天分别为DEHP的95％）。室内环境，尤其是粉尘摄入是造成BPA和DEHP暴露总量的主要非饮食因素，分别为60％和81％。但是，正如预期的那样，饮食对总暴露量的贡献更大，BPA> 99.9％，DEHP> 63％。尽管饮食被认为是接触BPA和邻苯二甲酸酯的主要来源，但必须考虑到，非饮食来源缺乏首过代谢，因此与饮食来源相比，它们的毒理学意义可能相同甚至更高。

本研究是在“基于大量人口调查的健康与环境协会”（HEALS）项目（FP7–603946）的框架内进行的。