Bicyclic and tricyclic C–C mismatch-binding ligands bind to CCG trinucleotide repeat DNAs†,Chemical Communications

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Bicyclic and tricyclic C–C mismatch-binding ligands bind to CCG trinucleotide repeat DNAs†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-05-31 00:00:00 , DOI: 10.1039/c8cc02393j
Tomonori Shibata _{1,

2,

3,

4} , Kazuhiko Nakatani _{1,

2,

3,

4}

Affiliation

We have reported bicyclic and tricyclic C–C mismatch-binding ligands that selectively bind to CCG trinucleotide repeat (TNR) DNAs. Bivalent interaction and enlarging the aromatic ring system of the cytosine-recognition unit led to the ligand binding to CCG TNRs accompanied by the formation of stable ligand–CCG TNR complexes and a large conformational change.

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