Catalytic enantioselective aldol reactions,Chemical Society Reviews

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Catalytic enantioselective aldol reactions
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2018-05-30 00:00:00 , DOI: 10.1039/c7cs00824d
Yasuhiro Yamashita _{1,

2,

3,

4,

5} , Tomohiro Yasukawa _{1,

2,

3,

4,

5} , Woo-Jin Yoo _{1,

2,

3,

4,

5} , Taku Kitanosono _{1,

2,

3,

4,

5} , Shū Kobayashi _{1,

2,

3,

4,

5}

Affiliation

Recent developments in catalytic asymmetric aldol reactions have been summarized. Enantioselective aldol reactions are important methods to synthesize β-hydroxy carbonyl compounds in optical pure form, and as such, numerous successful chiral catalysts were designed and applied for asymmetric aldol reactions. This review article is organized under the categories of: (1) catalytic enantioselective aldol reactions of preformed enolates, (2) catalytic enantioselective direct-type aldol reactions using chiral metal catalysts, (3) catalytic enantioselective direct-type aldol reactions using organocatalysts, (4) catalytic enantioselective aldol reactions in aqueous media. Examples of the aldol reactions that employ simple carbonyl compounds will be also the focus of this review.

中文翻译：

催化对映选择性醛醇缩合反应

已总结了催化不对称醛醇缩合反应的最新进展。对映选择性醛醇缩合反应是合成光学纯形式的β-羟基羰基化合物的重要方法，因此，设计了许多成功的手性催化剂并将其用于不对称醛醇缩合反应。这篇综述文章按以下类别组织：（1）预先形成的烯醇化物的催化对映体选择性醛醇缩合反应;（2）使用手性金属催化剂的催化对映体选择性直接醛醇缩合反应;（3）使用有机催化剂的催化对映体选择性直接醛醇缩合反应，（（ 4）在水性介质中的催化对映选择性醛醇缩合反应。采用简单的羰基化合物的醛醇缩合反应的例子也将是本综述的重点。

更新日期：2018-05-30

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