Dehydroxylation of alcohols for nucleophilic substitution†,Chemical Communications

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Dehydroxylation of alcohols for nucleophilic substitution†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-05-30 00:00:00 , DOI: 10.1039/c8cc03856b
Jia Chen _{1,

2,

3,

4,

5} , Jin-Hong Lin _{1,

2,

3,

4,

5} , Ji-Chang Xiao _{1,

2,

3,

4,

5}

Affiliation

The Ph₃P/ICH₂CH₂I system-promoted dehydroxylative substitution of alcohols was achieved to construct C–O, C–N, C–S and C–X (X = Cl, Br, and I) bonds. Compared with the previous approaches such as the Appel reaction and Mitsunobu reaction, this protocol offers some practical advantages such as safe operation and a convenient amination process.

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