Pyramidal cell regulation of interneuron survival sculpts cortical networks,Nature

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Pyramidal cell regulation of interneuron survival sculpts cortical networks
Nature ( IF 50.5 ) Pub Date : 2018-05-01 , DOI: 10.1038/s41586-018-0139-6
Fong Kuan Wong _{1,

2} , Kinga Bercsenyi _{1,

2} , Varun Sreenivasan _{1,

2} , Adrián Portalés _{1,

2} , Marian Fernández-Otero _{1,

2} , Oscar Marín _{1,

2}

Affiliation

Complex neuronal circuitries such as those found in the mammalian cerebral cortex have evolved as balanced networks of excitatory and inhibitory neurons. Although the establishment of appropriate numbers of these cells is essential for brain function and behaviour, our understanding of this fundamental process is limited. Here we show that the survival of interneurons in mice depends on the activity of pyramidal cells in a critical window of postnatal development, during which excitatory synaptic input to individual interneurons predicts their survival or death. Pyramidal cells regulate interneuron survival through the negative modulation of PTEN signalling, which effectively drives interneuron cell death during this period. Our findings indicate that activity-dependent mechanisms dynamically adjust the number of inhibitory cells in nascent local cortical circuits, ultimately establishing the appropriate proportions of excitatory and inhibitory neurons in the cerebral cortex.Excitatory input onto inhibitory interneurons in the developing mouse cortex acts through PTEN to protect interneurons from cell death and thus regulate the balance between excitation and inhibition.

中文翻译：

中间神经元存活的锥体细胞调节塑造了皮质网络

复杂的神经元回路，例如在哺乳动物大脑皮层中发现的回路，已经进化为兴奋性和抑制性神经元的平衡网络。尽管建立适当数量的这些细胞对大脑功能和行为至关重要，但我们对这一基本过程的理解是有限的。在这里，我们表明小鼠中间神经元的存活取决于锥体细胞在出生后发育的关键窗口中的活动，在此期间，对单个中间神经元的兴奋性突触输入预测它们的生存或死亡。锥体细胞通过对 PTEN 信号的负调节来调节中间神经元的存活，这在此期间有效地驱动中间神经元细胞死亡。

更新日期：2018-05-01

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