Photosensitizers with high photocleavage ability are urgently needed to improve photodynamic therapy efficacy. Herein, a supramolecular complex was constructed through host–guest self-assembly using hexa-β-CD-appended ruthenium polypyridyl (6CD-Ru) and adamantane-modified anthracene (ADA-AN) in water. The targeted DNA-intercalation of peripheral anthracenes can remarkably enhance photocleavage ability and antitumor activity of the complex irradiated with visible light.

中文翻译：

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通过超分子策略增强了β-环糊精附加Ru（II）配合物的DNA结合和光解能力

迫切需要具有高光裂解能力的光敏剂以改善光动力疗法的功效。在此，通过主客体自组装，使用六-β-CD附加的钌聚吡啶基钌（6CD-Ru）和金刚烷改性的蒽（ADA-AN），通过超客体组装而形成了超分子复合物。外围蒽的靶向DNA插入可以显着增强可见光照射的复合物的光裂解能力和抗肿瘤活性。