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Stimulated Motion Suppression (STMS): a New Approach to Break the Resolution Barrier for Ion Trap Mass Spectrometry
Journal of the American Society for Mass Spectrometry ( IF 3.1 ) Pub Date : 2018-05-29 , DOI: 10.1007/s13361-018-1995-x
Xiaoyu Zhou 1 , Xinwei Liu 1 , Spencer Chiang 1, 2 , Wenbo Cao 1 , Ming Li 1 , Zheng Ouyang 1, 2
Affiliation  

Ion trap is an excellent platform to perform tandem mass spectrometry (MS/MS), but has an intrinsic drawback in resolving power. Using ion resonant ejection as an example, the resolution degradation can be largely attributed to the broadening of the resonant frequency band (RFB) between ion motion and driving alternative-current (AC). To solve this problem, stimulated motion suppression (STMS) was developed. The key idea of STMS is the use of two suppression alternative-current (SAC) signals, which both have reversed initial phases to the main AC. The SACs can block the unexpected sideband ion resonances (or ejections), therefore playing a key role in sharpening the RFB. The proof-of-concept has been demonstrated through ion trajectory simulations and validated experimentally. STMS provides a new and versatile means for the improvement of the ion trap resolution, which for a long time has reached the bottleneck through conventional methods, e.g., increasing the radio-frequency (RF) voltage and decreasing the mass scan rate. At the end, it is worth noting that the idea of STMS is very general and principally can be applied in any RF device for the purposes of high-resolution mass analysis and ion isolation.

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中文翻译:

刺激运动抑制(STMS):打破离子阱质谱分析分辨率障碍的新方法

离子阱是执行串联质谱分析(MS / MS)的出色平台,但在分离能力方面存在固有的缺陷。以离子共振喷射为例,分辨率降低主要归因于离子运动与驱动交流电(AC)之间共振频带(RFB)的变宽。为了解决该问题,开发了刺激运动抑制(STMS)。STMS的关键思想是使用两个抑制交流电(SAC)信号,这两个信号的初始相位都与主交流电相反。SAC可以阻止意外的边带离子共振(或喷射),因此在锐化RFB中起关键作用。概念验证已通过离子轨迹模拟进行了证明,并进行了实验验证。STMS为提高离子阱的分辨率提供了一种新的通用方法,这种方法很长一段时间以来就已经通过常规方法达到了瓶颈,例如,增加射频(RF)电压和降低质量扫描速率。最后,值得注意的是,STMS的概念非常笼统,原则上可以应用于任何射频设备中,以进行高分辨率质量分析和离子隔离。

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更新日期:2018-05-29
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