Cumulative evidence has proven that proliferation, differentiation and migration of cardiac stem cells (CSCs) dominate early heart development and contribute to the later occurrence of heart disease. Among other mechanisms, microRNAs work as the 'fine-tuning' to modulate the levels of target genes in a specific cell type. The distinct microRNA signatures in CSCs reveal the stages and functions of CSCs. The focus of this review is to summarize recent knowledge advances in CSC proliferation, differentiation and migration and to discuss how microRNAs regulate these processes during heart development and in heart disease. Better understanding of microRNA regulation on CSCs under different situations will enable the unveiling of the mechanisms of heart disease and open new avenues in the therapeutic potentials of microRNA modulation to treat heart disease.

中文翻译：

---

microRNA和心脏干细胞在心脏发育和疾病中的作用。

累积证据已证明，心脏干细胞（CSC）的增殖，分化和迁移支配着心脏的早期发育，并助长了心脏病的后期发生。在其他机制中，microRNA作为“微调”来调节特定细胞类型中靶基因的水平。CSC中独特的microRNA标记揭示了CSC的阶段和功能。这篇综述的重点是总结在CSC增殖，分化和迁移方面的最新知识进展，并讨论microRNA在心脏发育和心脏病中如何调节这些过程。