Propiconazole (PCZ) is a triazole fungicide extensively used in agriculture. Carvacrol (CAR) is a naturally occurring phenolic monoterpene which has various biological and pharmacological effects. The present study was designed to investigate the neurobehavioral toxic effects of PCZ in albino rats and to evaluate the ameliorative role of CAR against such toxic effects. Sixty adult male rats were used in this investigation; they were randomly and equally divided into 4 groups: control group, PCZ group, CAR group and PCZ + CAR group. PCZ (75 mg/kg) and/or CAR (50 mg/kg) were administered daily by oral gavage for 8 weeks. Behavioral investigation clearly demonstrated the negative impact of PCZ on psychological, motor and cognitive brain functions. Exposure to PCZ also adversely affected the measured oxidative stress and lipid peroxidation parameters in brain tissue. A significant decrease in activity of acetylcholinesterase enzyme in neural tissue was also observed in PCZ-exposed rats. Histopathological examination of the cerebrum, cerebellum, and hippocampus showed various histopathological lesions after exposure to PCZ which were confirmed by immunohistochemical examination. On the other hand, co-administration of CAR ameliorated most of the undesirable effects of PCZ.

丙吡唑（PCZ）是广泛用于农业的三唑类杀菌剂。香芹酚（CAR）是天然存在的酚类单萜，具有多种生物学和药理作用。本研究旨在调查白化病大鼠中PCZ的神经行为毒性作用，并评估CAR对抗此类毒性作用的改善作用。60只成年雄性大鼠用于这项研究。将他们随机分为4组：对照组，PCZ组，CAR组和PCZ + CAR组。每天通过管饲法给予PCZ（75 mg / kg）和/或CAR（50 mg / kg），持续8周。行为研究清楚地证明了PCZ对心理，运动和认知脑功能的负面影响。暴露于PCZ也会对脑组织中测得的氧化应激和脂质过氧化参数产生不利影响。在暴露于PCZ的大鼠中，神经组织中乙酰胆碱酯酶的活性也显着下降。对大脑，小脑和海马的组织病理学检查显示，暴露于PCZ后，各种组织病理学病变均已通过免疫组织化学检查证实。另一方面，CAR的共同给药改善了PCZ的大部分不良作用。免疫组化检查证实，接触PCZ后海马和海马表现出各种组织病理学损害。另一方面，CAR的共同给药改善了PCZ的大部分不良作用。免疫组化检查证实，接触PCZ后海马和海马表现出各种组织病理学病变。另一方面，CAR的共同给药改善了PCZ的大部分不良作用。