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Visible light-induced aerobic oxidative cross-coupling of glycine derivatives with indoles: a facile access to 3,3′ bisindolylmethanes†
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2018-05-29 00:00:00 , DOI: 10.1039/c8qo00341f
Yuan Zhang 1, 2, 3, 4, 5 , Xiaorong Yang 1, 2, 3, 4, 5 , Huang Zhou 1, 2, 3, 4, 5 , Shilin Li 1, 2, 3, 4, 5 , Yin Zhu 1, 2, 3, 4, 5 , Ying Li 1, 2, 3, 4, 5
Affiliation  

A visible light-induced aerobic oxidative cross-coupling of glycine derivatives with indoles has been developed to efficiently synthesize 3,3′-bisindolylmethanes (BIMs). The reaction proceeds smoothly under mild conditions and exhibits good tolerance of functional groups. The applicability of this method was highlighted in the expedient total syntheses of the alkaloid natural products streptindole and arsindoline B in two steps, respectively.

中文翻译:

甘氨酸衍生物与吲哚的可见光诱导的有氧氧化交叉偶联:容易获得3,3'双吲哚甲烷

已经开发出可见光诱导的甘氨酸衍生物与吲哚的需氧氧化交叉偶联,以有效地合成3,3'-二吲哚基甲烷(BIM)。该反应在温和条件下平稳进行,并显示出对官能团的良好耐受性。该方法的适用性在生物碱天然产物链吲哚和arsindoline B的方便的总合成中分两步进行了强调。
更新日期:2018-05-29
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