An estrogen receptor targeted ruthenium complex as a two-photon photodynamic therapy agent for breast cancer cells†,Chemical Communications

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An estrogen receptor targeted ruthenium complex as a two-photon photodynamic therapy agent for breast cancer cells†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-05-29 00:00:00 , DOI: 10.1039/c8cc03786h
Xueze Zhao _{1,

2,

3,

4} , Mingle Li _{1,

2,

3,

4} , Wen Sun _{1,

2,

3,

4} , Jiangli Fan _{1,

2,

3,

4} , Jianjun Du _{1,

2,

3,

4} , Xiaojun Peng _{1,

2,

3,

4}

Affiliation

In this study, we reported a tamoxifen modified Ru(II) polypyridyl complex (Ru-tmxf) as an estrogen receptor (ER) targeted photosensitizer. Ru-tmxf displays enhanced cellular uptake and PDT efficiency toward breast cancer cells with high ER expression due to the specific targeting of tamoxifen to ER and finally localizes in lysosomes. Moreover, Ru-tmxf can be activated by two-photon excitation, generating ¹O₂ to damage lysosomes and result in cell death.

中文翻译：

靶向雌激素受体的钌配合物，作为乳腺癌细胞的双光子光动力治疗剂†

在这项研究中，我们报告了他莫昔芬修饰的Ru（II）聚吡啶基复合物（Ru-tmxf）作为雌激素受体（ER）的目标光敏剂。Ru-tmxf由于他莫昔芬特异性靶向ER而最终定位于溶酶体中，因此对具有高ER表达的乳腺癌细胞显示出增强的细胞摄取和PDT效率。此外，Ru-tmxf可以通过双光子激发而活化，产生¹ O ₂来破坏溶酶体并导致细胞死亡。

更新日期：2018-05-29

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