Straightforward and Sustainable Synthesis of Sulfonamides in Water under Mild Conditions,European Journal of Organic Chemistry

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Straightforward and Sustainable Synthesis of Sulfonamides in Water under Mild Conditions
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-17 , DOI: 10.1002/ejoc.201800504
Nadim Eid _{1,

2} , Iyad Karamé ₂ , Bruno Andrioletti ₁

Affiliation

A green, sustainable and chemoselective synthesis of sulfonamides using sodium sulfinate as a commercial and stable sulfur source and nitroarenes as the nitrogen‐containing reactant is described. The optimized conditions use water as solvent and the pure products are collected by simple filtration. The method is easily scalable and protecting‐group‐free because of the high functional tolerance.