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Gut Glucosinolate Metabolism and Isothiocyanate Production
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2018-07-05 , DOI: 10.1002/mnfr.201700991 Arjan Narbad 1 , John Trevor Rossiter 2
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2018-07-05 , DOI: 10.1002/mnfr.201700991 Arjan Narbad 1 , John Trevor Rossiter 2
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The glucosinolate‐myrosinase system in plants has been well studied over the years while relatively little research has been undertaken on the bacterial metabolism of glucosinolates. The products of myrosinase‐based glucosinolate hydrolysis in the human gut are important to health, particularly the isothiocyanates, as they are shown to have anticancer properties as well as other beneficial roles in human health. This review is concerned with the bacterial metabolism of glucosinolates but is not restricted to the human gut. Isothiocyanate production and nitrile formation are discussed together with the mechanisms of the formation of these compounds. Side chain modification of the methylsulfinylalkyl glucosinolates is reviewed and the implications for bioactivity of the resultant products are also discussed.
中文翻译：
肠道芥子油苷代谢和异硫氰酸盐生产
多年来，植物中的芥子油苷-黑芥子酶系统已得到充分研究，而对芥子油苷的细菌代谢的研究相对较少。人体肠道中基于黑芥子酶的芥子油苷水解产物对健康很重要，特别是异硫氰酸盐，因为它们被证明具有抗癌特性以及对人类健康的其他有益作用。本综述涉及芥子油苷的细菌代谢，但不限于人类肠道。讨论了异硫氰酸酯的生产和腈的形成以及这些化合物的形成机制。综述了甲基亚磺酰基烷基芥子油苷的侧链修饰，并讨论了所得产物的生物活性的影响。
更新日期：2018-07-05
中文翻译：
肠道芥子油苷代谢和异硫氰酸盐生产
多年来，植物中的芥子油苷-黑芥子酶系统已得到充分研究，而对芥子油苷的细菌代谢的研究相对较少。人体肠道中基于黑芥子酶的芥子油苷水解产物对健康很重要，特别是异硫氰酸盐，因为它们被证明具有抗癌特性以及对人类健康的其他有益作用。本综述涉及芥子油苷的细菌代谢，但不限于人类肠道。讨论了异硫氰酸酯的生产和腈的形成以及这些化合物的形成机制。综述了甲基亚磺酰基烷基芥子油苷的侧链修饰，并讨论了所得产物的生物活性的影响。
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