Synthesis of SAM‐Adenosine Conjugates for the Study of m6A‐RNA Methyltransferases,European Journal of Organic Chemistry

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Synthesis of SAM‐Adenosine Conjugates for the Study of m6A‐RNA Methyltransferases
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-16 , DOI: 10.1002/ejoc.201800798
Colette Atdjian ₁ , Laura Iannazzo ₁ , Emmanuelle Braud ₁ , Mélanie Ethève-Quelquejeu ₁

Affiliation

Methylation of the N‐6 adenosine of RNA is involved in the regulation of many biological processes. Bisubstrate analogues made of a SAM analogue and an adenosine unit were designed and synthesized for the study of RNA methyltransferases that catalyze the reaction of methylation.