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Synthesis of SAM‐Adenosine Conjugates for the Study of m6A‐RNA Methyltransferases
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-16 , DOI: 10.1002/ejoc.201800798
Colette Atdjian 1 , Laura Iannazzo 1 , Emmanuelle Braud 1 , Mélanie Ethève-Quelquejeu 1
Affiliation  

Methylation of the N‐6 adenosine of RNA is involved in the regulation of many biological processes. Bisubstrate analogues made of a SAM analogue and an adenosine unit were designed and synthesized for the study of RNA methyltransferases that catalyze the reaction of methylation.
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中文翻译:

SAM-腺苷缀合物的合成用于m6A-RNA甲基转移酶的研究

RNA的N-6腺苷的甲基化参与许多生物过程的调节。设计并合成了由SAM类似物和腺苷单元组成的双底物类似物,用于研究催化甲基化反应的RNA甲基转移酶。
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更新日期:2018-08-16
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